International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (1): 92-96.doi: 10.3760/ cma.j.issn.1673-5803.2023.01.017

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Application of aqueous humor liquid biopsy in diagnosis and treatment of retinoblastoma

Wang Nan, Li Jing, Ma Jianmin   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, China
  • Received:2022-06-26 Online:2023-02-22 Published:2023-03-11
  • Contact: Ma Jianmin, Email：jmma@sina.com E-mail:jmma@sina.com
  • Supported by:
    Natural Science Foundation of Beijing (7222025); Beijing Hospitals Authority’Ascent Plan (DFL20190201); Beijing Science and Technology Rising Star Program-Cross-Cooperation Project （20220484218）

Abstract: Retinoblastoma (RB) is the most common intraocular malignancy in children. Biopsy is contraindicated in RB due to its loose tumor tissue.Aqueous humor contains rich biological information and safe to access. Recent studies showed that the related biomarkers in aqueous humor, such as cell-free DNA, trefoil factor family, survivin and neuron-specific enolase, probably played the important roles in the early diagnosis, prediction of tumor invasiveness, observation of therapeutic effects, and evaluation of prognosis in children with RB may become a powerful tool for the diagnosis and efficacy observation of RB. (Int Rev Ophthalmol, 2023, 47: 92-96)

Key words: retinoblastoma, aqueous humor, cfDNA, trefoil factor family, survivin